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streptomycin
Columbia Encyclopedia entry: streptomycin
Streptomycinstrĕp′tōmī'sĭn, antibiotic produced by soil bacteria of the genus Streptomyces and active against both gram-positive and gram-negative bacteria (see Gram's stain), including species resistant to other antibiotics, e.g., some streptococci, penicillin-resistant staphylococci, and bacteria of the genera Proteus and Pseudomonas. Originally isolated by Selman A. Waksman and Albert Schatz in 1947, streptomycin is effective against tubercle bacilli and is a mainstay of tuberculosis therapy. Because streptomycin-resistant tubercle bacilli emerge during treatment, the antibiotic is usually used in combination with one or more of the drugs isoniazid, ethambutol, and aminosalicylic acid. Streptomycin acts by inhibiting protein synthesis and damaging cell membranes in susceptible microorganisms. Possible side effects include injury to the kidneys and nerve damage that can result in dizziness and deafness.
Wikipedia search results for: Streptomycin
From Wikipedia, the free encyclopedia
Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. It is derived from the actinobacterium Streptomyces griseus. Streptomycin is a bactericidal antibiotic . Streptomycin cannot be given orally, but must be administered by regular intramuscular injections. An adverse effect of this medicine is ototoxicity, which can lead to hearing loss. Streptomycin is a protein synthesis inhibitor. It binds to the S12 Protein of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit. This prevents...more »
Columbia Encyclopedia search results: streptomycin
Results 1 - 8  of 8
  • Streptomyces

    Streptomyces, bacterial genus of the order Actinomycetales, members of which resemble fungi in their branching filamentous structure. Various species produce such antibiotics as streptomycin a...

  • isoniazid

    Isoniazid, drug used to treat tuberculosis. Also known as isonicotinic acid hydrazide, isoniazid is the most effective antituberculosis drug currently available. The drug inhibits or kills the...

  • Waksman, Selman Abraham

    Waksman, Selman Abraham, 1888–1973, American microbiologist, b. Priluka, Russia, grad. Rutgers (B.S. 1915), Ph.D. Univ. of California, 1918. He went to the United States in 1910 and was natura...

  • antibiotic

    Antibiotic, any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. The great number of diverse antibiotics cu...

  • drug poisoning

    Drug poisoning, toxic effects caused by an administered drug. Worldwide more than 9 million natural and synthetic chemicals have been identified; fewer than 3000 cause more than 95% of acident...

  • plague

    Plague, any contagious, malignant, epidemic disease, in particular the bubonic plague and the black plague (or Black Death), both forms of the same infection. These acute febrile diseases are ...

  • deafness

    Deafness, partial or total lack of hearing. It may be present at birth (congenital) or may be acquired at any age thereafter. A person who cannot detect sound at an amplitude of 20 decibels in...

  • protein

    Protein, any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% ...

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