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pancreas
Columbia Encyclopedia entry: pancreas
Pancreaspăn'krēəs, glandular organ that secretes digestive enzymes and hormones. In humans, the pancreas is a yellowish organ about 7 in. (17.8 cm) long and 1.5 in. (3.8 cm) wide. It lies beneath the stomach and is connected to the small intestine at the duodenum (see digestive system). Most of the pancreatic tissue consists of grapelike clusters of cells that produce a clear fluid (pancreatic juice) that flows into the duodenum through a common duct along with bile from the liver. Pancreatic juice contains three digestive enzymes: tryptase, amylase, and lipase, that, along with intestinal enzymes, complete the digestion of proteins, carbohydrates, and fats, respectively. Scattered among the enzyme-producing cells of the pancreas are small groups of endocrine cells, called the islets of Langerhans, that secrete two hormones, insulin and glucagon. The pancreatic islets contain several types of cells: alpha-2 cells, which produce the hormone glucagon; beta cells, which manufacture the hormone insulin; and alpha-1 cells, which produce the regulatory agent somatostatin. These hormones are secreted directly into the bloodstream, and together, they regulate the level of glucose in the blood. Insulin lowers the blood sugar level and increases the amount of glycogen (stored carbohydrate) in the liver; glucagon has the opposite action. Failure of the insulin-secreting cells to function properly results in diabetes, which can occur in two major forms, the division being between juvenile onset and onset in maturity. Pancreatic cancer has a particularly high mortality rate, and patients with a family history of the disease sometimes have the pancreas removed if precancerous cysts are present in the organ.
Wikipedia search results for: Pancreas
From Wikipedia, the free encyclopedia
The pancreas is a gland organ in the digestive and endocrine system of vertebrates. It is both an endocrine gland producing several important hormones, including insulin, glucagon, and somatostatin, as well as an exocrine gland, secreting pancreatic juice containing digestive enzymes that pass to the small intestine. These enzymes help in the further breakdown of the carbohydrates, protein, and fat in the chyme. Under a microscope, stained sections of the pancreas reveal two different types of parenchymal tissue. Lightly staining clusters of cells are called islets of Langerhans, which produce hormones that underlie the endocrine functions of the...more »
Columbia Encyclopedia search results: pancreas
Results 1 - 10  of 24
  • sweetbread

    Sweetbread. The thymus gland (known as throat sweetbread) and the pancreas (stomach sweetbread), especially of the calf and lamb (although beef sweetbreads are sometimes eaten), are considered...

  • hyperinsulinism

    Hyperinsulinism, presence in the system of an above-normal amount of insulin, the substance secreted by the pancreas and needed by the body to utilize sugar. An increased amount of insulin in ...

  • pancreatic juice

    Pancreatic juice, secretions of the exocrine portion of the pancreas into the small intestine. The juice contains a number of important digestive enzymes, including trypsin, chymotrypsin, carb...

  • glucagon

    Glucagon, hormone secreted by the α cells of the islets of Langerhans, specific groups of cells in the pancreas. It tends to counteract the action of insulin, i.e., it raises the concentration...

  • insulin

    Insulin, hormone secreted by the ß cells of the islets of Langerhans, specific groups of cells in the pancreas. Insufficiency of insulin in the body results in diabetes. Insulin was one of the...

  • diabetes

    Diabetes or diabetes mellitus, chronic disorder of glucose (sugar) metabolism caused by inadequate production or use of insulin, a hormone produced in specialized cells (beta cells in the isle...

  • chymotrypsin

    Chymotrypsin, proteolytic, or protein-digesting, enzyme active in the mammalian intestinal tract. It catalyzes the hydrolysis of proteins, degrading them into smaller molecules called peptides...

  • Cohnheim, Julius

    Cohnheim, Julius, 1839–84, German experimental histologist and pathologist. In a relatively brief life Cohnheim made a series of remarkable contributions to the rapidly developing science of p...

  • abdomen

    Abdomen, in humans and other vertebrates, portion of the trunk between the diaphragm and lower pelvis. In humans the wall of the abdomen is a muscular structure covered by fascia, fat, and ski...

  • Banting, Sir Frederick Grant

    Banting, Sir Frederick Grant, 1891–1941, Canadian physician, M.D. Univ. of Toronto, 1922. From 1923 he was professor of medical research at Toronto. Working with C. H. Best under the direction...

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