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Columbia Encyclopedia entry: liver
Liver, largest glandular organ of the body, weighing about 3 lb (1.36 kg). It is reddish brown in color and is divided into four lobes of unequal size and shape. The liver lies on the right side of the abdominal cavity beneath the diaphragm. Blood is carried to the liver via two large vessels: the hepatic artery carries oxygen-rich blood from the aorta, and the portal vein carries blood containing digested food from the small intestine. These blood vessels subdivide in the liver repeatedly, terminating in minute capillaries. Each capillary leads to a lobule. Liver tissue is composed of thousands of lobules, and each lobule is made up of hepatic cells, the basic metabolic cells of the liver. One of the liver's major functions is the manufacture and secretion of bile, which is stored in the gall bladder and released in the small intestine. Bile salts emulsify fats, a process that prepares the latter for digestion by the intestinal enzymes (see digestive system). The hepatic cells assimilate carbohydrates, fats, and proteins. They convert glucose to its stored form, glycogen, which is reconverted into glucose as the body requires it for energy. The ability of the liver to maintain the proper level of glucose in the blood is called its glucose buffer function. The end products of fat digestion, fatty acids, are used to synthesize cholesterol and other substances needed by the body. Excess carbohydrates and protein are also converted into fat by the liver. Digested proteins in the form of amino acids are broken down further in the liver by deamination. Part of the amino acid molecule is converted into glycogen and other compounds. Urea, a waste product of protein breakdown, is produced by the liver, a process which removes poisonous ammonia from the body fluids. The liver is also capable of synthesizing certain amino acids (the so-called nonessential amino acids) from other amino acids in a process called transamination. Some essential components of blood are manufactured by the liver, including about 95% of the plasma proteins and the blood-clotting substances (fibrinogen, prothrombin, and other coagulation factors). The liver also filters harmful substances from the blood. Phagocytic cells in the liver, called Kupffer cells, remove large amounts of debris and bacteria. In addition, the liver stores important vitamins and minerals, including vitamins A, D, K, and B12. Several diseases states can affect the liver, such as hepatitis (an inflammation of the liver) and cirrhosis (a chronic inflammation that progresses ultimately to organ failure). Alcohol alters the metabolism of the liver, which can have overall detrimental effects over long periods of abuse. In 1994, a bioartificial liver, part machine, part cloned living liver cells, was used for the first time. Functioning somewhat like a kidney dialysis machine, the bioartificial liver can support patients with acute liver failure until their own livers regenerate, or it can be used by patients while waiting for a liver transplant.
Wikipedia search results for: Liver
From Wikipedia, the free encyclopedia
The liver is a vital organ present in vertebrates and some other animals; it has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion. The liver is necessary for survival; there is currently no way to compensate for the absence of liver function. This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the thoracic region of the abdomen. It produces bile, an alkaline compound which aids in...more »
Columbia Encyclopedia search results: liver
Results 1 - 10  of 117
  • foie gras

    Foie gras [Fr.,=fat liver], livers of artificially fattened geese. Ducks and chickens are also sometimes used in the making of foie gras. The birds, kept in close coops to prevent exercise, ar...

  • cirrhosis

    Cirrhosis, degeneration of tissue in an organ resulting in fibrosis, with nodule and scar formation. The term is most often used in relation to the liver, because that organ is most often invo...

  • glycogen

    Glycogen, starchlike polysaccharide (see carbohydrate) that is found in the liver and muscles of humans and the higher animals and in the cells of the lower animals. Chemically it is a highly ...

  • heparin

    Heparin, anticoagulant produced by cells in many animals. A polysaccharide, heparin is found in the human body and occurs in greatest concentration in the tissues surrounding the capillaries o...

  • hepatitis

    Hepatitis, inflammation of the liver. There are many types of hepatitis. Causes include viruses, toxic chemicals, alcohol consumption, parasites and bacteria, and certain drugs. Symptoms of he...

  • Reye's syndrome

    Reye's syndrome, rare but life-threatening disease characterized by acute encephalopathy and fatty infiltration of internal organs, especially the liver. It occurs almost entirely in children ...

  • cortisol

    Cortisol or hydrocortisone, steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland. Like cortisone, cortisol is classed as a glucoc...

  • corticosterone

    Corticosterone, steroid hormone secreted by the outer layer, or cortex, of the adrenal gland. Classed as a glucocorticoid, corticosterone helps regulate the conversion of amino acids into carb...

  • diuretic

    Diuretic, drug used to increase urine formation and output. Diuretics are prescribed for the treatment of edema (the accumulation of excess fluids in the tissues of the body), which is often t...

  • gall bladder

    Gall bladder, small pear-shaped sac that stores and concentrates bile. It is connected to the liver (which produces the bile) by the hepatic duct. When food containing fat reaches the small in...

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