Removal does not physically interfere with sexual activity, but it does eliminate the uterine contractions of orgasm. It also eliminates the possibility of childbearing and precipitates menopause in premenopausal women. Surgical removal of the ovaries eliminates their production of estrogen and progesterone along with these hormones's protective benefits to the heart, bones, and skin.

Some women's health advocates have questioned what they feel is the overuse of hysterectomy in the United States, where it is the second most common surgical procedure. Some studies have judged that up to 25% of hysterectomies performed in the United States are unnecessary and that more conservative treatments (laparoscopic surgery, hormone therapy, or simple removal of fibroids) would suffice in these cases.